Aclasta 5mg/100mL

 
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Best Value On Brand Aclasta 5mg/100mL
Price: $7.18 per ml!
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Aclasta 5mg/100mL Prescription Required
100 ml for $717.97 ($7.18 per ml)
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About Aclasta

What Aclasta is used for

ACLASTA is the brand name for the active ingredient zoledronic acid 5 mg/100 mL.

ACLASTA is used:

  • In the treatment of osteoporosis in postmenopausal women to reduce the risk of hip, vertebral, non-vertebral fractures (breaking bone) when given once a year.

  • In the treatment to increase bone mineral density in men with osteoporosis when given once a year.

  • In the treatment and prevention of osteoporosis, in men and women caused by glucocorticoid medicines such as prednisone, to increase bone mineral density, when given once a year.

  • In the treatment of Paget’s disease when given as a single treatment.

What Aclasta does

ACLASTA binds specifically to bone and it does not stay in your blood. ACLASTA slows down bone resorption (caused by osteoclasts) which allows the bone-forming cells (osteoblasts) time to rebuild normal bone.

Zoledronic acid is a member of a class of the nonhormonal drugs called bisphosphonates.

How is normal bone maintained?

Bone undergoes a normal process of rebuilding that occurs continuously throughout your skeleton. First, old bone is removed (resorbed) by bone-resorbing cells (osteoclasts), then new bone is laid down (formed) by bone-forming cells (osteoblasts). This balanced process of resorbing and forming bone keeps your skeleton healthy and strong.

What is osteoporosis?

Osteoporosis is a disease that involves the thinning and weakening of the bones, which is common in women after the menopause and may also occur in men. At the menopause, a woman’s ovaries stop producing the female hormone, estrogen, which helps keep bones healthy. Following the menopause bone loss occurs, bones become weaker, and break more easily. Many women with osteoporosis have no symptoms but they are still at risk of breaking bones because osteoporosis has made their bones weaker.

What is Paget's disease of bone?

In Paget’s disease, bone breaks down too much and the new bone made is not normal. If Paget’s disease is not treated, bones like the skull, spine, and legs become deformed and weaker than normal. This can cause problems like bone pain and arthritis. The bones can also break easily. Paget’s disease of bone sometimes runs in families. Paget’s disease may be discovered by X-ray examination or blood tests.

When Aclasta should not be used

You should not be treated with ACLASTA if you:

  • Have been told by your doctor that you currently have low calcium levels in your blood (Hypocalcemia) or vitamin D deficiency

  • Are pregnant or plan to become pregnant.

  • Are breast-feeding.

  • Are allergic (hypersensitive) to zoledronic acid or any of the other ingredients of ACLASTA. There is a list of what is in ACLASTA below. See What the important nonmedicinal ingredients are:.

  • Are allergic to any other bisphosphonate such as Actonel (risedronate), Fosamax (alendronate), Aredia (pamidronate), Zometa (zoledronic acid 4 mg), Didronel/Didrocal (etidronate), Bonefos (clodronate) or Bondronat (ibandronate). This list is not complete; please check with your doctor or pharmacist.

What the medicinal ingredient is:

The active ingredient in ACLASTA is zoledronic acid.

What the important nonmedicinal ingredients for Aclasta are

Mannitol, sodium citrate, water for injection.

What dosage forms Aclasta comes in

ACLASTA 5 mg/100 mL is a solution for intravenous infusion and it comes in a 100 mL plastic bottle as a ready-to-use solution. The bottle has a convenient plastic hanger to help your doctor or nurse facilitate the infusion set-up. Each infusion of 100 mL solution delivers 5 mg of zoledronic acid. Keep the original packaging unchanged and sealed until the doctor or the nurse administers ACLASTA.


Warnings and Precautions

Be sure that you have discussed ACLASTA treatment with your doctor. BEFORE you take ACLASTA talk to your doctor or pharmacist if you:

  • Are less than 18 years of age

  • Are unable to take daily calcium and/or vitamin D supplements

  • Are pregnant or plan to become pregnant

  • Are breast-feeding

  • Have, or used to have, a kidney problem

  • Had some or all of your parathyroid glands or thyroid gland surgically removed

  • Had sections of your intestine removed

  • Need any dental procedures such as a root canal or tooth extraction (this does not include regular dental cleaning). Your doctor may possibly request a dental examination with any necessary preventive dentistry carried out prior to treatment with ACLASTA. You should continue regular dental cleanings and practice good oral hygiene.

  • Have irregular heart beat

  • Have asthma from taking ASA (acetylsalicylic acid such as Aspirin)

If you are being treated with another intravenous form of zoledronic acid (i.e. Zometa), you should not be treated with ACLASTA.

If you are being treated with ACLASTA, you should not be treated with other bisphosphonates (such as alendronate, risedronate, clodronate, etidronate, ibandronate and pamidonate) at the same time.

ACLASTA is to be given by intravenous infusion in no less than 15 minutes.


Interactions with Aclasta

While being treated with ACLASTA, can I take coffee, tea, juice, milk or food?

Yes. There is no restriction on what you can drink or eat and when you can drink or eat. Since, ACLASTA is given as an infusion and avoids the stomach, its interaction with food has not been studied.

While being treated with ACLASTA, can I take other medications?

Tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including any you have bought without a prescription. It is especially important for your doctor to know if you are taking any medicines known to be harmful to your kidneys (such as nonsteroidal anti-inflammatory drugs (NSAIDs)). Tell your doctor if you are taking water pill (diuretics) or aminoglycoside antibiotics (a type of medicine used to treat severe infections). Because ACLASTA is given as an infusion and avoids the stomach, you can take your vitamin D, mineral supplements and anti-acids at any time of the day as directed by your doctor.

Can I continue my daily activities?

After your ACLASTA infusion, there is no restriction on your normal activities such as standing, sitting, taking a walk or exercising.


Proper Use of Aclasta

What should I know before taking ACLASTA?

Be sure that you drink a sufficient amount of water (at least two glasses, 500 mL or 2 cups) before and after your treatment with ACLASTA. You may eat and drink normally on the day you are treated with ACLASTA.

How is ACLASTA given?

ACLASTA is given as an infusion into a vein for 15 minutes by your doctor or nurse.

Usual dose

For Osteoporosis: single dose of 5 mg once yearly.

For Paget’s disease: single treatment of 5 mg.

The infusion nurse or doctor may ask you to stay for a short period of time after the infusion.

Technical Information