Ezetrol 10 mg

Generic Name: Ezetimibe 10 mg
Ezetrol 10 mg Image

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Ezetrol Facts

As of 2009 Ezetrol is not known to be marketed in the USA.

EZETROL tm is a registered trademark of MSP Singapore Company, LLC

Ezetrol tablets contain the active ingredient ezetimibe which acts by decreasing cholesterol absorption in the intestine.

Ezetrol* (ezetimibe), was the first of a new class of cholesterol-lowering agents since the introduction of statins to the Canadian market.


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Ezetrol 10 mg is available from our online pharmacy for less money than you'd spend locally. If you like the convenience of ordering from your home, you can order your prescription online, or speak with one of our customer service representatives on the phone. Call us, The Drug Company, toll free at 1-888-254-3038. Prior to taking Ezetrol 10 mg, please consult with your doctor or health professional to see if this medication is right for you. Many customers have saved even more money by speaking with their doctor about a generic substitute.

Ezetrol General Information

Ezetrol is the registered trademark of MSP Singapore Company, LLC. Ezetrol (Ezetimibe) is recommended primarily for the treatment of hypercholesterolemia, a homozygous low-density lipoprotein receptor disorder, according to the National Institute of Health. It is primarily recognized as Ezetrol in European and Asian nations. In the United States it is marketed as Zetia alone or as Vytorin or Inegy with statins.

This is typically a treatment option for patients whose cholesterol is not controlled by the initial statin after the appropriate dosage. The National Institute of Health showed evidence that Ezetimibe or Ezetrol with statin therapy reduced LDL cholesterol by 23.2 percent more than statin therapy alone. Doubling the dose of statin therapy or switching to an alternative statin generally lead to a further reduction of LDL-cholesterol concentrations in the blood plasma.

How does Ezetrol work?

Ezetrol is used to lower cholesterol levels and acts by inhibiting cholesterol absorption in the small intestine. Ezetrol appears to binds to the Niemann-Pick C1-Like 1 (NPC1L1) protein on the gastrointestinal tract epithelial cells and hepatocytes. The NPC1L1 is a critical mediator of cholesterol absorption. This process decreases intestinal delivery of cholesterol to the liver. The result yields a decreased cholesterol level. Decreased cholesterol absorption also leads to a regulation of LDL-receptors on the surface of the cells and an increased LDL-cholesterol uptake into the cells. This process decreases the levels of LDL in the blood plasma which can contribute to atherosclerosis and cardiovascular occurrences.

When/How is Ezetrol taken/used/applied?

Ezetrol is available in 10 mg tablets. The recommended dose of Ezetrol is a 10 mg tablet once daily with a glass of water. Ezetrol is eliminated from the blood plasma within 22 hours allowing for once daily dosage. The medication can be taken with or without food.

Ezetrol should not be taken with cyclosporine, fenofibrate or gemfibrozil due to increased Ezetrol blood level. Fibrates may increase the risk of cholesterol excretion into the gallbladder. Chelostyramine may decrease Ezetrol blood level. Immunosuppressants may increase bone marrow depression and increase immunosuppression.

Ezetrol may also interact with antacids, herbal medicines that lower cholesterol or other medication that lower cholesterol or triglycerides. This list may not describe all possible interactions. Consult your physician before combining other medications with Ezetrol.

Other items that may cause complications are smoking, alcohol, and illegal drugs.

Side Effects of Ezetrol

Patients may experience skin rash, itching or hives, characteristic of anaphylaxis and swelling of the face, lips or tongue, characteristic of angioedema. Some patients have reported fatigue, yellowing of the skin or eyes and dark yellow or brown urine. If the patient experiences any of these symptoms he or she should consult your physician immediately.

If the patient experiences diarrhea, dizziness, headache, stomach upset or pain, medical attention is generally not required unless the symptoms are persistent or unbearable.

Also consult your physician if you have unexplained muscle pain, characteristic of myalgia, weakness, characteristic of myopathy or tenderness.

Some other side effects include gastro-intestinal disturbances, and rarely, arthralgia, hepatitis, pancreatitis, cholelithiasis, cholecystitis, thrombocytopenia, raised creatine kinase, and rhabdommyolysis.

Other Brand Names for Ezetrol:

Zetia
Vytorin (Ezetimibe with statins)
Inegy (Ezetimibe with statins)
Ezetimibe (generic)

Safety Information:

Patients are advised not to get pregnant or try to get pregnant while taking this medication. Patients are also advised not to breastfeed while taking this medication. If you have liver disease or suffer from allergic reactions to Ezetimibe or Ezertrol, other medicines, food, dyes or preservatives, consult a physician before taking the medication.

Dosage:

Tablet/Pill 10 mg once per day

Visual Description:

The oral pill is white and oblong in shape with side 1:414.

About Ezetrol

What Ezetrol is used for

EZETROL helps to reduce the amount of cholesterol and triglycerides in your blood in conjunction with lifestyle changes including exercise, diet, and weight management, when a response to such changes has been inadequate.

Cholesterol is one of several fatty substances found in the bloodstream. Your total cholesterol is made up mainly of low density lipoprotein cholesterol and high density lipoprotein cholesterol (LDL and HDL cholesterol).

LDL cholesterol is often called “bad” cholesterol because it can build up in the walls of your arteries forming plaque. Eventually this plaque build-up can lead to a narrowing of the arteries. This narrowing can slow or block blood flow to vital organs such as the heart and brain. This blocking of blood flow can result in a heart attack or stroke.

HDL cholesterol is often called “good” cholesterol because it helps keep the bad cholesterol from building up in the arteries and protects against heart disease.

Triglycerides are another form of fat in your blood that may increase your risk for heart disease.

EZETROL may be taken alone or with other cholesterol-lowering medicines known as statins or with another medicine known as fenofibrate, in addition to diet and other lifestyle changes (see Interactions with This Medication:). EZETROL adds to the cholesterol-lowering effect of statins and fenofibrate. Statins and fenofibrate lower cholesterol in a different way; they work in the liver.

What Ezetrol does

EZETROL works by decreasing the absorption of cholesterol in the small intestine.

When Ezetrol should not be used

  • Patients who are hypersensitive (allergic) to ezetimibe or any of the nonmedicinal ingredients should not take EZETROL.

  • Patients with liver disease, active or unexplained increases in liver enzymes (blood tests of liver function) should not take EZETROL together with a statin.

  • Patients who are pregnant should not take EZETROL together with a statin.

  • Patients who are nursing should not take EZETROL together with a statin.

What the medicinal ingredient is

Ezetimibe.

What the important nonmedicinal ingredients for Ezetrol are

Croscarmellose sodium, lactose monohydrate, magnesium stearate, microcrystalline cellulose, povidone, and sodium lauryl sulfate.

What dosage forms Ezetrol comes in

Tablet 10 mg (white to off-white).


Warnings and Precautions

Serious Warnings and Precautions

  • Liver disease (Hepatitis)

  • Pancreas disease (Pancreatitis)

  • Muscle pain (Myopathy/Rhabdomyolysis, myalgia)

  • Severe allergic reaction (Anaphylaxis)

Before you use EZETROL talk to your doctor if you

  • are pregnant, plan to become pregnant or think you might be pregnant.

  • are breast-feeding. EZETROL may be passed in your milk to your baby.

  • have now or have had in the past any medical problems (including liver disease or liver problems).


Interactions with Ezetrol

You should always tell your doctor about all drugs that you are taking or plan to take as well as those obtained without a prescription.

Drugs that may interact with EZETROL include:

  • Cyclosporine

  • Cholestyramine (a resine/bile acid sequestrant) or any other bile acid sequestrant. In that case, EZETROL should be taken at least 2 hours before or 4 hours after taking the bile acid sequestrant.

  • Fibrates


Proper Use of Ezetrol

Usual dose

  • EZETROL should be taken as directed. Take one 10 mg tablet by mouth each day, preferably at the same time of day. EZETROL can be taken with or without food.

  • Continue taking your other cholesterol-lowering medicines known as statins or fenofibrate unless your doctor tells you to stop.

  • If you are taking a statin or fenofibrate, EZETROL can be taken at the same time.

  • Even if you are taking medication to treat high cholesterol, it is important to have your cholesterol measured regularly. You should also know your cholesterol levels and goals.

Overdose

Take EZETROL only as prescribed for you. If you take more EZETROL than you were prescribed, contact your doctor or pharmacist.

For management of a suspected drug overdose, contact your regional Poison Control Centre.

Missed dose

If you miss a dose, just resume the usual schedule of one tablet daily.


Side Effects for Ezetrol and What to Do About Them

EZETROL is generally well tolerated.

  • When used alone, the following common side effects have been reported: abdominal pain, diarrhea, tiredness, viral infection, throat infection (pharyngitis), nose infection (sinusitis), joint pain (arthralgia), back pain, and coughing.

  • When used with a statin, the following common side effects have been reported: headache, tiredness, abdominal pain, diarrhea, joint pain (arthralgia), muscle pain (myalgia), back pain, throat infection (pharyngitis), nose infection (sinusitis), upper chest infection (respiratory tract), and changes in certain laboratory blood tests.

  • In general use, the following side effects have been reported: dizziness, depression and tingling sensation.

  • You should contact your doctor if you develop persistent and severe muscle aches or pains with no obvious explanation at any time after starting to take EZETROL.

If you are prescribed EZETROL with a statin, your doctor will order routine blood tests to check your liver function before and after starting treatment.

Talk to your doctor anytime you have a medical problem you think may be related to EZETROL.

Serious Side Effects, How Often They Happen and What to Do About Them
Symptoms/effects Talk with your doctor or pharmacist Stop taking drug and call your doctor or pharmacist
Only if severe In all cases
Rare Muscle aches and pains (Myopathy/Rhabdomyolysis)    
Sudden severe allergic reactions (swelling of the face, lips, tongue, and/or throat that may cause difficulty in breathing or swallowing, rash and hives).    
Symptoms of liver problems (severe abdominal pain, especially if felt on the upper right side below the ribs, dark urine, general itchiness, severe nausea or vomiting, pale stools, yellowing of skin or eyes)    
Symptoms of gallstones or inflammation of the gallbladder (severe abdominal pain, nausea, vomiting)    
Symptoms of pancreas problems (severe abdominal pain)    

This is not a complete list of side effects. For any unexpected effects while taking EZETROL, contact your doctor or pharmacist.


Technical Information

What Others Are Saying About ezetrol:

Alberto Peeples on Tuesday March 24, 2009

Recently, I switched from Ezetrol to generic Ezetimibe, and didn't notice any difference, so I'll keep buying the Ezetimibe online from your website because it helps me save money. I'm grateful for your refill service -- I'm a busy person and your refill reminders let me know when it's time to buy another three month supply, or if my prescription needs to be updated.

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