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Emcyt 140 mg Prescription Required
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Emcyt from online pharmacy: Canada

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About Emcyt

What Emcyt is used for

EMCYT is used for the treatment of metastatic cancer of the prostate in patients whose disease is not responding to hormone therapy.

What Emcyt does

EMCYT interferes with the growth of tumour cells and may also help to slow down the growth of prostate cancer cells.

When Emcyt should not be used

Do not take EMCYT if you have any of the following conditions:

allergic reactions to estramustine sodium phosphate, or estradiol, or nitrogen mustard, or any of the other ingredients in EMCYT
severe liver disease
severe heart disease
active inflammation of veins (thrombophlebitis) or blood clot disorders.

What the medicinal ingredient is

The medicinal ingredient is estramustine sodium phosphate.

What the important nonmedicinal ingredients for Emcyt are

Nonmedicinal ingredients include magnesium stearate, silica (colloidal anhydrous), sodium lauryl sulphate, and talc.

What dosage forms Emcyt comes in

EMCYT is available as 140 mg capsules.

Warnings and Precautions

Serious Warnings and Precautions

EMCYT should be prescribed and used under the supervision of a doctor experienced in the use of cancer drugs.

BEFORE you use EMCYT talk to your doctor or pharmacist if you:

Have or had severe liver disease
Have or had blood clot disorders
Have a history of stroke or heart disease
Have swelling of the legs or heart failure
Have high blood pressure
Have bone disease associated with high calcium levels
Have kidney problems
Have diabetes

Patients receiving chemotherapy agents, including EMCYT, should not be given live vaccines, or be in contact with any person who has received live vaccines, as this may result in serious infections and death.

A male patient and his female partner must use effective contraceptive methods as EMCYT can cause harm to an unborn child.

Interactions with Emcyt

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

Drugs that may interact with EMCYT include:

tricyclic antidepressants.
supplements or antacids that contain calcium or milk products.
ACE-Inhibitors (drugs to treat high blood pressure).

Proper Use of Emcyt

Usual dose

The recommended dose of EMCYT is 14 mg for every kg of body weight each day. The total dose is given in 3 or 4 divided doses during the day.

The capsules should be taken on an empty stomach, at least 1 hour before or 2 hours after meals.

The capsules should be swallowed with a glass of water. Do not take with milk, milk products or calcium containing drugs (for example, antacids).

Overdose

If you think you may have accidentally taken too many EMCYT capsules, talk to your doctor or call a poison control centre immediately. You may require medical attention.

Missed dose

If you miss a dose of this medicine, skip the missed dose and go back to your regular dosing schedule. Do not double dose.

Side Effects for Emcyt and What to Do About Them

Common side effects: stomach upset, nausea, and occasionally vomiting.

Uncommon side effects: allergic skin rashes, swelling, chest pain, blood clots, heart failure, heart attack, high blood pressure, breast tenderness or pain, decreased interest in having sex (libido), and difficulty in getting an erection (impotence)

Rare side effects: abnormal lab results, anemia, muscle weakness, depression, headache, confusion, fatigue, and diarrhea.

Serious Side Effects, How Often They Happen and What to Do About Them
Symptom/Effect		Talk with your doctor or pharmacist		Stop taking drug and call your doctor or pharmacist
Symptom/Effect		Only if severe	In all cases	Stop taking drug and call your doctor or pharmacist
Common	Nausea, diarrhea, stomach upset	•
Uncommon	Allergic reaction/anaphylaxis/angioedema (itching, hives, swelling, tightness in chest, trouble breathing)			•
	Blood clot (pain, redness, warmth, swelling in the leg)			•
	Heart attack and heart failure (sudden or severe chest pain, trouble breathing)			•
	Stroke (sudden or severe headache, confusion, weakness or numbness in arm and leg, and vision problems)			•

This is not a complete list of side effects. For any unexpected effects while taking EMCYT, contact your doctor or pharmacist.

Technical Information

Information for the Patient

Emcyt

Pharmacology

Estramustine has a dual mode of action. The intact molecule acts as an antimitotic agent and after hydrolysis of the carbamate ester bridge the released estrogens exert an antigonadotrophic effect. The low level of clinically manifested side effects may be due to the fact that estramustine binds to a protein present in the tumor tissue, which results in an accumulation of the drug at the target site.

Indications

The treatment of metastatic prostatic carcinoma (stage D) in patients whose disease is refractory to hormonal therapy. Estramustine may produce either a stabilization or regression of the disease process and improvement in ability to function.

Precautions

Food/Drug Interactions

Effects on Ability to Drive and Use Machines

Supplied

Each white, opaque, hard gelatin capsule contains: estramustine sodium phosphate 140 mg. Nonmedicinal ingredients: gelatin capsule, isopropanol, magnesium stearate, silica and sodium laurylsulfate. Bisulfite-, gluten-, lactose- and tartrazine-free. Bottles of 100. Store at 2 to 25°C.

Contraindications

In patients with any of the following conditions: known hypersensitivity to either estradiol or to nitrogen mustard, severe hepatic or cardiac disease or active thrombophlebitis or thromboembolic disorders.

Warnings

Estramustine should be used with caution in patients with a history of thrombophlebitis, thrombosis or thromboembolic disorders, especially if associated with estrogen therapy. Caution should also be used in patients with cerebral vascular or coronary artery disease.

Angioneurotic edema has been reported in few cases during estramustine therapy, with or without concomitant medication.

Glucose Tolerance: Because glucose tolerance may be decreased, diabetic patients should be carefully observed while receiving estramustine.

Elevated Blood Pressure: Because hypertension may occur, blood pressure should be monitored periodically.

Adverse Effects

Gastrointestinal disturbances (most commonly transient nausea, but occasionally vomiting, and rarely diarrhea) sometimes occur during the first two weeks of therapy. In a few cases thrombocytopenia, leukopenia and elevated transaminases/bilirubin have been noted but were completely reversible on reduction of dosage or temporary (1 to 2 weeks) withdrawal of the drug. Other cases of anemia, muscular weakness, depression, headache, confusion and lethargy may rarely occur. A few cases of allergic skin rashes, edema and anginal complaints have been reported. Cardiovascular adverse reactions such as fluid retention/edema, thromboembolism, ischemic heart disease, congestive heart failure, myocardial infarction and hypertension may occur during treatment. A few cases of angioneurotic edema have been reported during estramustine therapy, with or without concomitant medication. Therapy with estramustine is to be immediately discontinued, should angioneurotic edema occur. As with conventional estradiol therapy, thromboembolic disorders, gynecomastia, reduced libido and potency may occur.

Overdose

Symptoms

Treatment

Dosage

The recommended dose of estramustine is 14 mg/kg of body weight/day (i.e., one 140 mg capsule for each 10 kg), given in 3 or 4 divided doses. Most patients have been treated at a dose range of 10 to 16 mg/kg/day.

Treatment for at least 30 days is recommended before assessing the benefits of therapy and may be continued as long as a favorable response lasts. If no response is observed after 4-6 weeks, treatment should be discontinued. Some patients have been maintained on therapy for more than 2 years at doses ranging from 10 to 16 mg/kg of body weight/day.

The capsules should be taken at not less than 1 hour before or 2 hours after meals.

The capsules should be swallowed with a glass of water. Milk, milk products or calcium containing drugs (such as calcium-containing antacids) must not be used simultaneously with estramustine capsules.

Emcyt 140 mg

Ask A Pharmacist

About Emcyt

What Emcyt is used for

What Emcyt does

When Emcyt should not be used

What the medicinal ingredient is

What the important nonmedicinal ingredients for Emcyt are

What dosage forms Emcyt comes in

Warnings and Precautions

Interactions with Emcyt

Drugs that may interact with EMCYT include:

Proper Use of Emcyt

Usual dose

Overdose

Missed dose

Side Effects for Emcyt and What to Do About Them

Information for the Patient

Pharmacology

Indications

Precautions

Food/Drug Interactions

Effects on Ability to Drive and Use Machines

Supplied

Contraindications

Warnings

Adverse Effects

Overdose

Symptoms

Treatment

Dosage

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